Intralesional Therapy

Intralesional therapy is a procedure in which a drug is injected directly into a skin lesion for faster action. In many cases, intralesional therapy eliminates the need for long term oral or topical therapy. It can be very effective as the injection works deep into the tissue where topical medications cannot penetrate.
Intralesional injection has been an important part of dermatologic therapy since first introduced in 1961 . Intralesional injections are effective for a wide range of indications, are easily performed, and are relatively safe.
The rationale for intralesional therapy is simple: to deliver a medication directly into a specific skin lesion to treat local tissues with minimal systemic effects. The skin also serves as a reservoir, allowing medication deposited in the dermis to be delivered over a period of time, resulting in prolonged therapy while avoiding or minimizing the adverse effects of systemic therapy.


The drugs primarily used for intralesional injections are

  1. 5-fluorouracil,
  2. Methotrexate,
    6.Sodium Stibogluconate
  3. Sodium tetradecyl sulfate
    9.PRP (Platelets Rich Plasma)
    10.Zinc sulphate 2%
    Intralesional steroid injection
    Intralesional steroid injection involves a corticosteroid such as triamcinolone acetonide suspension